| 09/02/06 | hosting | Eastern Kentucky | 31-0 |
| 09/08/06 | hosting | Pittsburgh | 15-33 |
| 09/16/06 | at | Ohio State | 7-37 |
| 09/23/06 | at | Virginia Tech | 13-29 |
| 09/30/06 | hosting | Miami OH | 24-10 |
| 10/07/06 | hosting | Akron | 20-14 |
| 10/14/06 | at | Louisville | 17-23 |
| 10/22/06 | hosting | South Florida | 23-6 |
| 10/28/06 | hosting | Syracuse | 17-3 |
| 11/11/06 | at | West Virginia | 24-42 |
| 11/18/06 | hosting | Rutgers | 30-11 |
| 11/25/06 | at | Connecticut | 26-23 |
| 01/06/07 | at | Western Michigan | 27-24 |