| 11/18/05 | hosting | Lafayette | 70-47 |
| 11/21/05 | at | Fairfield | 72-41 |
| 11/26/05 | at | Davidson | 94-100 OT |
| 11/29/05 | at | Drexel | 69-59 |
| 12/06/05 | vs. | Kansas | 70-67 |
| 12/10/05 | hosting | Ohio St. | 74-81 |
| 12/21/05 | at | Bucknell | 51-63 |
| 12/28/05 | at | St. Mary's | 70-66 |
| 12/31/05 | at | Gonzaga | 94-102 |
| 01/04/06 | hosting | Xavier | 58-62 |
| 01/08/06 | hosting | Temple | 59-57 |
| 01/11/06 | at | Massachusetts | 58-68 |
| 01/14/06 | at | George Washington | 70-82 |
| 01/17/06 | hosting | Charlotte | 50-57 |
| 01/21/06 | hosting | La Salle | 66-54 |
| 01/25/06 | at | St. Louis | 54-39 |
| 01/28/06 | at | Pennsylvania | 47-44 |
| 02/01/06 | at | Dayton | 69-77 |
| 02/04/06 | hosting | St. Bonaventure | 82-51 |
| 02/07/06 | vs. | Villanova | 58-71 |
| 02/11/06 | hosting | George Washington | 62-64 |
| 02/14/06 | at | Temple | 44-57 |
| 02/18/06 | at | Rhode Island | 57-55 |
| 02/22/06 | hosting | Fordham | 64-58 |
| 02/25/06 | hosting | Richmond | 70-39 |
| 02/28/06 | at | Xavier | 68-58 |
| 03/04/06 | at | Duquesne | 79-63 |
| 03/08/06 | vs. | Dayton | 67-55 |
| 03/09/06 | vs. | St. Louis | 56-37 |
| 03/10/06 | vs. | Temple | 73-59 |
| 03/11/06 | at | Xavier | 61-62 |
| 03/16/06 | hosting | Rutgers | 71-62 |
| 03/20/06 | hosting | Hofstra | 75-77 OT |