| 09/01/05 | hosting | Oregon | 24-38 |
| 09/10/05 | hosting | Sam Houston State | 31-10 |
| 09/16/05 | at | UTEP | 41-44 OT |
| 10/01/05 | at | Tulsa | 30-23 |
| 10/08/05 | vs. | Tulane | 35-14 |
| 10/15/05 | hosting | Memphis | 20-35 |
| 10/22/05 | at | Mississippi State | 28-16 |
| 11/05/05 | at | Central Florida | 29-31 |
| 11/13/05 | hosting | Southern Miss | 27-24 |
| 11/19/05 | hosting | SMU | 24-29 |
| 11/26/05 | hosting | Rice | 35-18 |
| 12/23/05 | vs. | Kansas | 13-42 |