| 09/03/05 | hosting | Baylor | 23-28 |
| 09/10/05 | hosting | TCU | 21-10 |
| 09/17/05 | at | Texas A&M | 8-66 |
| 09/24/05 | hosting | Tulane | 10-31 |
| 10/01/05 | at | Marshall | 13-16 OT |
| 10/08/05 | at | Alabama-Birmingham | 28-27 |
| 10/15/05 | hosting | East Carolina | 17-24 |
| 10/22/05 | at | Tulsa | 13-20 |
| 11/05/05 | hosting | Rice | 27-7 |
| 11/19/05 | at | Houston | 29-24 |
| 11/26/05 | hosting | UTEP | 40-27 |