| 10/15/05 | at | Connecticut | 1-3 |
| 10/22/05 | hosting | Colgate | 1-1 OT |
| 10/23/05 | hosting | Colgate | 4-1 |
| 10/29/05 | at | Northeastern | 5-1 |
| 10/30/05 | hosting | Northeastern | 6-1 |
| 11/05/05 | at | St. Lawrence | 1-6 |
| 11/06/05 | at | Clarkson | 2-4 |
| 11/12/05 | hosting | Maine | 3-3 OT |
| 11/13/05 | hosting | Maine | 4-3 |
| 11/17/05 | hosting | Vermont | 6-1 |
| 11/19/05 | hosting | Boston University | 4-0 |
| 11/25/05 | hosting | Yale | 3-1 |
| 11/26/05 | hosting | Brown | 5-3 |
| 11/30/05 | hosting | Harvard | 3-6 |
| 12/03/05 | at | Boston University | 1-2 |
| 12/04/05 | at | Boston College | 4-2 |
| 12/10/05 | hosting | Dartmouth | 1-2 |
| 01/02/06 | at | Princeton | 2-1 |
| 01/07/06 | hosting | Niagara | 6-4 |
| 01/08/06 | hosting | Mercyhurst | 2-5 |
| 01/14/06 | hosting | Minnesota State | 3-3 OT |
| 01/15/06 | hosting | Minnesota State | 6-2 |
| 01/21/06 | hosting | Northeastern | 5-4 OT |
| 01/22/06 | at | Maine | 2-2 OT |
| 01/29/06 | at | New Hampshire | 2-7 |
| 02/01/06 | hosting | New Hampshire | 1-2 |
| 02/04/06 | at | Vermont | 4-1 |
| 02/05/06 | at | Vermont | 5-1 |
| 02/11/06 | hosting | Boston University | 6-1 |
| 02/12/06 | at | New Hampshire | 1-4 |
| 02/18/06 | hosting | Boston College | 1-4 |
| 02/19/06 | at | Boston College | 2-4 |
| 02/25/06 | at | Connecticut | 1-2 |
| 02/26/06 | hosting | Connecticut | 5-2 |
| 03/04/06 | vs. | Boston College | 1-3 |