| 10/21/05 | hosting | New Hampshire | 0-6 |
| 10/22/05 | hosting | New Hampshire | 2-8 |
| 10/29/05 | vs. | Vermont | 3-1 |
| 10/30/05 | vs. | Boston College | 1-1 OT |
| 11/04/05 | at | Mercyhurst | 0-3 |
| 11/05/05 | at | Mercyhurst | 2-5 |
| 11/11/05 | hosting | Cornell | 3-1 |
| 11/12/05 | hosting | Cornell | 2-6 |
| 11/19/05 | at | Colgate | 1-3 |
| 11/20/05 | at | Colgate | 4-2 |
| 11/25/05 | at | Brown | 2-1 |
| 11/26/05 | vs. | Yale | 1-9 |
| 12/02/05 | at | St. Cloud State | 1-4 |
| 12/03/05 | at | St. Cloud State | 2-4 |
| 12/09/05 | hosting | Clarkson | 4-1 |
| 12/10/05 | hosting | Clarkson | 1-0 |
| 01/07/06 | at | Providence | 4-6 |
| 01/08/06 | at | Connecticut | 0-8 |
| 01/13/06 | at | Ohio State | 1-1 OT |
| 01/14/06 | at | Ohio State | 2-2 OT |
| 01/21/06 | hosting | Mercyhurst | 1-2 |
| 01/22/06 | hosting | Mercyhurst | 1-3 |
| 01/27/06 | hosting | St. Lawrence | 0-3 |
| 01/28/06 | hosting | St. Lawrence | 3-6 |
| 02/04/06 | at | Robert Morris | 0-0 OT |
| 02/05/06 | at | Robert Morris | 0-1 |
| 02/11/06 | hosting | Robert Morris | 8-1 |
| 02/12/06 | hosting | Robert Morris | 3-4 |
| 02/17/06 | at | Wayne State | 0-4 |
| 02/18/06 | at | Wayne State | 1-2 |
| 02/25/06 | at | Northeastern | 0-3 |
| 02/26/06 | at | Northeastern | 5-2 |
| 03/03/06 | hosting | Wayne State | 3-2 |
| 03/04/06 | hosting | Wayne State | 2-1 OT |
| 03/09/06 | at | Wayne State | 4-3 OT |
| 03/12/06 | vs. | Mercyhurst | 2-6 |