| 09/10/06 | at | Kansas City | 23-10 |
| 09/17/06 | hosting | Cleveland | 34-17 |
| 09/24/06 | at | Pittsburgh | 28-20 |
| 10/01/06 | hosting | New England | 13-38 |
| 10/15/06 | at | Tampa Bay | 13-14 |
| 10/22/06 | hosting | Carolina | 17-14 |
| 10/29/06 | hosting | Atlanta | 27-29 |
| 11/05/06 | at | Baltimore | 20-26 |
| 11/12/06 | hosting | San Diego | 41-49 |
| 11/19/06 | at | New Orleans | 31-16 |
| 11/26/06 | at | Cleveland | 30-0 |
| 11/30/06 | hosting | Baltimore | 13-7 |
| 12/10/06 | hosting | Oakland | 27-10 |
| 12/18/06 | at | Indianapolis | 16-34 |
| 12/24/06 | at | Denver | 23-24 |
| 12/31/06 | hosting | Pittsburgh | 17-23 OT |