| 09/10/06 | hosting | Cincinnati | 10-23 |
| 09/17/06 | at | Denver | 6-9 OT |
| 10/01/06 | hosting | San Francisco | 41-0 |
| 10/08/06 | at | Arizona | 23-20 |
| 10/15/06 | at | Pittsburgh | 7-45 |
| 10/22/06 | hosting | San Diego | 30-27 |
| 10/29/06 | hosting | Seattle | 35-28 |
| 11/05/06 | at | St. Louis | 31-17 |
| 11/12/06 | at | Miami | 10-13 |
| 11/19/06 | hosting | Oakland | 17-13 |
| 11/23/06 | hosting | Denver | 19-10 |
| 12/03/06 | at | Cleveland | 28-31 OT |
| 12/10/06 | hosting | Baltimore | 10-20 |
| 12/17/06 | at | San Diego | 9-20 |
| 12/23/06 | at | Oakland | 20-9 |
| 12/31/06 | hosting | Jacksonville | 35-30 |
| 01/06/07 | at | Indianapolis | 8-23 |