| 09/11/06 | at | Oakland | 27-0 |
| 09/17/06 | hosting | Tennessee | 40-7 |
| 10/01/06 | at | Baltimore | 13-16 |
| 10/08/06 | hosting | Pittsburgh | 23-13 |
| 10/15/06 | at | San Francisco | 48-19 |
| 10/22/06 | at | Kansas City | 27-30 |
| 10/29/06 | hosting | St. Louis | 38-24 |
| 11/05/06 | hosting | Cleveland | 32-25 |
| 11/12/06 | at | Cincinnati | 49-41 |
| 11/19/06 | at | Denver | 35-27 |
| 11/26/06 | hosting | Oakland | 21-14 |
| 12/03/06 | at | Buffalo | 24-21 |
| 12/10/06 | hosting | Denver | 48-20 |
| 12/17/06 | hosting | Kansas City | 20-9 |
| 12/24/06 | at | Seattle | 20-17 |
| 12/31/06 | hosting | Arizona | 27-20 |
| 01/14/07 | hosting | New England | 21-24 |