| 09/10/06 | at | Tampa Bay | 27-0 |
| 09/17/06 | hosting | Oakland | 28-6 |
| 09/24/06 | at | Cleveland | 15-14 |
| 10/01/06 | hosting | San Diego | 16-13 |
| 10/09/06 | at | Denver | 3-13 |
| 10/15/06 | hosting | Carolina | 21-23 |
| 10/29/06 | at | New Orleans | 35-22 |
| 11/05/06 | hosting | Cincinnati | 26-20 |
| 11/12/06 | at | Tennessee | 27-26 |
| 11/19/06 | hosting | Atlanta | 24-10 |
| 11/26/06 | hosting | Pittsburgh | 27-0 |
| 11/30/06 | at | Cincinnati | 7-13 |
| 12/10/06 | at | Kansas City | 20-10 |
| 12/17/06 | hosting | Cleveland | 27-17 |
| 12/24/06 | at | Pittsburgh | 31-7 |
| 12/31/06 | hosting | Buffalo | 19-7 |
| 01/13/07 | hosting | Indianapolis | 6-15 |