| 09/10/06 | at | St. Louis | 10-18 |
| 09/17/06 | hosting | Kansas City | 9-6 OT |
| 09/24/06 | at | New England | 17-7 |
| 10/09/06 | hosting | Baltimore | 13-3 |
| 10/15/06 | hosting | Oakland | 13-3 |
| 10/22/06 | at | Cleveland | 17-7 |
| 10/29/06 | hosting | Indianapolis | 31-34 |
| 11/05/06 | at | Pittsburgh | 31-20 |
| 11/12/06 | at | Oakland | 17-13 |
| 11/19/06 | hosting | San Diego | 27-35 |
| 11/23/06 | at | Kansas City | 10-19 |
| 12/03/06 | hosting | Seattle | 20-23 |
| 12/10/06 | at | San Diego | 20-48 |
| 12/17/06 | at | Arizona | 37-20 |
| 12/24/06 | hosting | Cincinnati | 24-23 |
| 12/31/06 | hosting | San Francisco | 23-26 OT |