| 09/10/06 | hosting | San Francisco | 34-27 |
| 09/17/06 | at | Seattle | 10-21 |
| 09/24/06 | hosting | St. Louis | 14-16 |
| 10/01/06 | at | Atlanta | 10-32 |
| 10/08/06 | hosting | Kansas City | 20-23 |
| 10/16/06 | hosting | Chicago | 23-24 |
| 10/22/06 | at | Oakland | 9-22 |
| 10/29/06 | at | Green Bay | 14-31 |
| 11/12/06 | hosting | Dallas | 10-27 |
| 11/19/06 | hosting | Detroit | 17-10 |
| 11/26/06 | at | Minnesota | 26-31 |
| 12/03/06 | at | St. Louis | 34-20 |
| 12/10/06 | hosting | Seattle | 27-21 |
| 12/17/06 | hosting | Denver | 20-37 |
| 12/24/06 | at | San Francisco | 26-20 |
| 12/31/06 | at | San Diego | 20-27 |