| 09/10/06 | at | Green Bay | 26-0 |
| 09/17/06 | hosting | Detroit | 34-7 |
| 09/24/06 | at | Minnesota | 19-16 |
| 10/01/06 | hosting | Seattle | 37-6 |
| 10/08/06 | hosting | Buffalo | 40-7 |
| 10/16/06 | at | Arizona | 24-23 |
| 10/29/06 | hosting | San Francisco | 41-10 |
| 11/05/06 | hosting | Miami | 13-31 |
| 11/12/06 | at | N.Y. Giants | 38-20 |
| 11/19/06 | at | N.Y. Jets | 10-0 |
| 11/26/06 | at | New England | 13-17 |
| 12/03/06 | hosting | Minnesota | 23-13 |
| 12/11/06 | at | St. Louis | 42-27 |
| 12/17/06 | hosting | Tampa Bay | 34-31 OT |
| 12/24/06 | at | Detroit | 26-21 |
| 12/31/06 | hosting | Green Bay | 7-26 |
| 01/14/07 | hosting | Seattle | 27-24 OT |
| 01/21/07 | hosting | New Orleans | 39-14 |
| 02/04/07 | vs. | Indianapolis | 17-29 |