| 09/11/06 | at | Washington | 19-16 |
| 09/17/06 | hosting | Carolina | 16-13 OT |
| 09/24/06 | hosting | Chicago | 16-19 |
| 10/01/06 | at | Buffalo | 12-17 |
| 10/08/06 | hosting | Detroit | 26-17 |
| 10/22/06 | at | Seattle | 31-13 |
| 10/30/06 | hosting | New England | 7-31 |
| 11/05/06 | at | San Francisco | 3-9 |
| 11/12/06 | hosting | Green Bay | 17-23 |
| 11/19/06 | at | Miami | 20-24 |
| 11/26/06 | hosting | Arizona | 31-26 |
| 12/03/06 | at | Chicago | 13-23 |
| 12/10/06 | at | Detroit | 30-20 |
| 12/17/06 | hosting | N.Y. Jets | 13-26 |
| 12/21/06 | at | Green Bay | 7-9 |
| 12/31/06 | hosting | St. Louis | 21-41 |