| 09/07/06 | at | Pittsburgh | 17-28 |
| 09/17/06 | hosting | Buffalo | 6-16 |
| 09/24/06 | hosting | Tennessee | 13-10 |
| 10/01/06 | at | Houston | 15-17 |
| 10/08/06 | at | New England | 10-20 |
| 10/15/06 | at | N.Y. Jets | 17-20 |
| 10/22/06 | hosting | Green Bay | 24-34 |
| 11/05/06 | at | Chicago | 31-13 |
| 11/12/06 | hosting | Kansas City | 13-10 |
| 11/19/06 | hosting | Minnesota | 24-20 |
| 11/23/06 | at | Detroit | 27-10 |
| 12/03/06 | hosting | Jacksonville | 10-24 |
| 12/10/06 | hosting | New England | 21-0 |
| 12/17/06 | at | Buffalo | 0-21 |
| 12/25/06 | hosting | N.Y. Jets | 10-13 |
| 12/31/06 | at | Indianapolis | 22-27 |