| 09/10/06 | hosting | Seattle | 6-9 |
| 09/17/06 | at | Chicago | 7-34 |
| 09/24/06 | hosting | Green Bay | 24-31 |
| 10/01/06 | at | St. Louis | 34-41 |
| 10/08/06 | at | Minnesota | 17-26 |
| 10/15/06 | hosting | Buffalo | 20-17 |
| 10/22/06 | at | N.Y. Jets | 24-31 |
| 11/05/06 | hosting | Atlanta | 30-14 |
| 11/12/06 | hosting | San Francisco | 13-19 |
| 11/19/06 | at | Arizona | 10-17 |
| 11/23/06 | hosting | Miami | 10-27 |
| 12/03/06 | at | New England | 21-28 |
| 12/10/06 | hosting | Minnesota | 20-30 |
| 12/17/06 | at | Green Bay | 9-17 |
| 12/24/06 | hosting | Chicago | 21-26 |
| 12/31/06 | at | Dallas | 39-31 |