| 09/10/06 | at | Jacksonville | 17-24 |
| 09/17/06 | hosting | Washington | 27-10 |
| 10/01/06 | at | Tennessee | 45-14 |
| 10/08/06 | at | Philadelphia | 24-38 |
| 10/15/06 | hosting | Houston | 34-6 |
| 10/23/06 | hosting | N.Y. Giants | 22-36 |
| 10/29/06 | at | Carolina | 35-14 |
| 11/05/06 | at | Washington | 19-22 |
| 11/12/06 | at | Arizona | 27-10 |
| 11/19/06 | hosting | Indianapolis | 21-14 |
| 11/23/06 | hosting | Tampa Bay | 38-10 |
| 12/03/06 | at | N.Y. Giants | 23-20 |
| 12/10/06 | hosting | New Orleans | 17-42 |
| 12/16/06 | at | Atlanta | 38-28 |
| 12/25/06 | hosting | Philadelphia | 7-23 |
| 12/31/06 | hosting | Detroit | 31-39 |
| 01/06/07 | at | Seattle | 20-21 |