| 09/10/06 | at | Detroit | 9-6 |
| 09/17/06 | hosting | Arizona | 21-10 |
| 09/24/06 | hosting | N.Y. Giants | 42-30 |
| 10/01/06 | at | Chicago | 6-37 |
| 10/15/06 | at | St. Louis | 30-28 |
| 10/22/06 | hosting | Minnesota | 13-31 |
| 10/29/06 | at | Kansas City | 28-35 |
| 11/06/06 | hosting | Oakland | 16-0 |
| 11/12/06 | hosting | St. Louis | 24-22 |
| 11/19/06 | at | San Francisco | 14-20 |
| 11/27/06 | hosting | Green Bay | 34-24 |
| 12/03/06 | at | Denver | 23-20 |
| 12/10/06 | at | Arizona | 21-27 |
| 12/14/06 | hosting | San Francisco | 14-24 |
| 12/24/06 | hosting | San Diego | 17-20 |
| 12/31/06 | at | Tampa Bay | 23-7 |
| 01/06/07 | hosting | Dallas | 21-20 |
| 01/14/07 | at | Chicago | 24-27 OT |