| 09/10/06 | at | Arizona | 27-34 |
| 09/17/06 | hosting | St. Louis | 20-13 |
| 09/24/06 | hosting | Philadelphia | 24-38 |
| 10/01/06 | at | Kansas City | 0-41 |
| 10/08/06 | hosting | Oakland | 34-20 |
| 10/15/06 | hosting | San Diego | 19-48 |
| 10/29/06 | at | Chicago | 10-41 |
| 11/05/06 | hosting | Minnesota | 9-3 |
| 11/12/06 | at | Detroit | 19-13 |
| 11/19/06 | hosting | Seattle | 20-14 |
| 11/26/06 | at | St. Louis | 17-20 |
| 12/03/06 | at | New Orleans | 10-34 |
| 12/10/06 | hosting | Green Bay | 19-30 |
| 12/14/06 | at | Seattle | 24-14 |
| 12/24/06 | hosting | Arizona | 20-26 |
| 12/31/06 | at | Denver | 26-23 OT |