| 09/10/06 | hosting | Chicago | 0-26 |
| 09/17/06 | hosting | New Orleans | 27-34 |
| 09/24/06 | at | Detroit | 31-24 |
| 10/02/06 | at | Philadelphia | 9-31 |
| 10/08/06 | hosting | St. Louis | 20-23 |
| 10/22/06 | at | Miami | 34-24 |
| 10/29/06 | hosting | Arizona | 31-14 |
| 11/05/06 | at | Buffalo | 10-24 |
| 11/12/06 | at | Minnesota | 23-17 |
| 11/19/06 | hosting | New England | 0-35 |
| 11/27/06 | at | Seattle | 24-34 |
| 12/03/06 | hosting | N.Y. Jets | 10-38 |
| 12/10/06 | at | San Francisco | 30-19 |
| 12/17/06 | hosting | Detroit | 17-9 |
| 12/21/06 | hosting | Minnesota | 9-7 |
| 12/31/06 | at | Chicago | 26-7 |