| 09/10/06 | at | Houston | 24-10 |
| 09/17/06 | hosting | N.Y. Giants | 24-30 OT |
| 09/24/06 | at | San Francisco | 38-24 |
| 10/02/06 | hosting | Green Bay | 31-9 |
| 10/08/06 | hosting | Dallas | 38-24 |
| 10/15/06 | at | New Orleans | 24-27 |
| 10/22/06 | at | Tampa Bay | 21-23 |
| 10/29/06 | hosting | Jacksonville | 6-13 |
| 11/12/06 | hosting | Washington | 27-3 |
| 11/19/06 | hosting | Tennessee | 13-31 |
| 11/26/06 | at | Indianapolis | 21-45 |
| 12/04/06 | hosting | Carolina | 27-24 |
| 12/10/06 | at | Washington | 21-19 |
| 12/17/06 | at | N.Y. Giants | 36-22 |
| 12/25/06 | at | Dallas | 23-7 |
| 12/31/06 | hosting | Atlanta | 24-17 |
| 01/07/07 | hosting | N.Y. Giants | 23-20 |
| 01/13/07 | at | New Orleans | 24-27 |