| 09/10/06 | hosting | Dallas | 24-17 |
| 09/18/06 | hosting | Pittsburgh | 9-0 |
| 09/24/06 | at | Indianapolis | 14-21 |
| 10/01/06 | at | Washington | 30-36 OT |
| 10/08/06 | hosting | N.Y. Jets | 41-0 |
| 10/22/06 | at | Houston | 7-27 |
| 10/29/06 | at | Philadelphia | 13-6 |
| 11/05/06 | hosting | Tennessee | 37-7 |
| 11/12/06 | hosting | Houston | 10-13 |
| 11/20/06 | hosting | N.Y. Giants | 26-10 |
| 11/26/06 | at | Buffalo | 24-27 |
| 12/03/06 | at | Miami | 24-10 |
| 12/10/06 | hosting | Indianapolis | 44-17 |
| 12/17/06 | at | Tennessee | 17-24 |
| 12/24/06 | hosting | New England | 21-24 |
| 12/31/06 | at | Kansas City | 30-35 |