| 09/10/06 | at | N.Y. Giants | 26-21 |
| 09/17/06 | hosting | Houston | 43-24 |
| 09/24/06 | hosting | Jacksonville | 21-14 |
| 10/01/06 | at | N.Y. Jets | 31-28 |
| 10/08/06 | hosting | Tennessee | 14-13 |
| 10/22/06 | hosting | Washington | 36-22 |
| 10/29/06 | at | Denver | 34-31 |
| 11/05/06 | at | New England | 27-20 |
| 11/12/06 | hosting | Buffalo | 17-16 |
| 11/19/06 | at | Dallas | 14-21 |
| 11/26/06 | hosting | Philadelphia | 45-21 |
| 12/03/06 | at | Tennessee | 17-20 |
| 12/10/06 | at | Jacksonville | 17-44 |
| 12/18/06 | hosting | Cincinnati | 34-16 |
| 12/24/06 | at | Houston | 24-27 |
| 12/31/06 | hosting | Miami | 27-22 |
| 01/06/07 | hosting | Kansas City | 23-8 |
| 01/13/07 | at | Baltimore | 15-6 |
| 01/21/07 | hosting | New England | 38-34 |
| 02/04/07 | vs. | Chicago | 29-17 |