| 09/07/06 | hosting | Miami | 28-17 |
| 09/18/06 | at | Jacksonville | 0-9 |
| 09/24/06 | hosting | Cincinnati | 20-28 |
| 10/08/06 | at | San Diego | 13-23 |
| 10/15/06 | hosting | Kansas City | 45-7 |
| 10/22/06 | at | Atlanta | 38-41 OT |
| 10/29/06 | at | Oakland | 13-20 |
| 11/05/06 | hosting | Denver | 20-31 |
| 11/12/06 | hosting | New Orleans | 38-31 |
| 11/19/06 | at | Cleveland | 24-20 |
| 11/26/06 | at | Baltimore | 0-27 |
| 12/03/06 | hosting | Tampa Bay | 20-3 |
| 12/07/06 | hosting | Cleveland | 27-7 |
| 12/17/06 | at | Carolina | 37-3 |
| 12/24/06 | hosting | Baltimore | 7-31 |
| 12/31/06 | at | Cincinnati | 23-17 OT |