| 09/10/06 | at | Carolina | 20-6 |
| 09/17/06 | hosting | Tampa Bay | 14-3 |
| 09/25/06 | at | New Orleans | 3-23 |
| 10/01/06 | hosting | Arizona | 32-10 |
| 10/15/06 | hosting | N.Y. Giants | 14-27 |
| 10/22/06 | hosting | Pittsburgh | 41-38 OT |
| 10/29/06 | at | Cincinnati | 29-27 |
| 11/05/06 | at | Detroit | 14-30 |
| 11/12/06 | hosting | Cleveland | 13-17 |
| 11/19/06 | at | Baltimore | 10-24 |
| 11/26/06 | hosting | New Orleans | 13-31 |
| 12/03/06 | at | Washington | 24-14 |
| 12/10/06 | at | Tampa Bay | 17-6 |
| 12/16/06 | hosting | Dallas | 28-38 |
| 12/24/06 | hosting | Carolina | 3-10 |
| 12/31/06 | at | Philadelphia | 17-24 |