| 09/10/06 | hosting | New Orleans | 14-19 |
| 09/17/06 | at | Cincinnati | 17-34 |
| 09/24/06 | hosting | Baltimore | 14-15 |
| 10/01/06 | at | Oakland | 24-21 |
| 10/08/06 | at | Carolina | 12-20 |
| 10/22/06 | hosting | Denver | 7-17 |
| 10/29/06 | hosting | N.Y. Jets | 20-13 |
| 11/05/06 | at | San Diego | 25-32 |
| 11/12/06 | at | Atlanta | 17-13 |
| 11/19/06 | hosting | Pittsburgh | 20-24 |
| 11/26/06 | hosting | Cincinnati | 0-30 |
| 12/03/06 | hosting | Kansas City | 31-28 OT |
| 12/07/06 | at | Pittsburgh | 7-27 |
| 12/17/06 | at | Baltimore | 17-27 |
| 12/24/06 | hosting | Tampa Bay | 7-22 |
| 12/31/06 | at | Houston | 6-14 |