| 09/11/06 | hosting | San Diego | 0-27 |
| 09/17/06 | at | Baltimore | 6-28 |
| 10/01/06 | hosting | Cleveland | 21-24 |
| 10/08/06 | at | San Francisco | 20-34 |
| 10/15/06 | at | Denver | 3-13 |
| 10/22/06 | hosting | Arizona | 22-9 |
| 10/29/06 | hosting | Pittsburgh | 20-13 |
| 11/06/06 | at | Seattle | 0-16 |
| 11/12/06 | hosting | Denver | 13-17 |
| 11/19/06 | at | Kansas City | 13-17 |
| 11/26/06 | at | San Diego | 14-21 |
| 12/03/06 | hosting | Houston | 14-23 |
| 12/10/06 | at | Cincinnati | 10-27 |
| 12/17/06 | hosting | St. Louis | 0-20 |
| 12/23/06 | hosting | Kansas City | 9-20 |
| 12/31/06 | at | N.Y. Jets | 3-23 |