| 09/10/06 | hosting | Denver | 18-10 |
| 09/17/06 | at | San Francisco | 13-20 |
| 09/24/06 | at | Arizona | 16-14 |
| 10/01/06 | hosting | Detroit | 41-34 |
| 10/08/06 | at | Green Bay | 23-20 |
| 10/15/06 | hosting | Seattle | 28-30 |
| 10/29/06 | at | San Diego | 24-38 |
| 11/05/06 | hosting | Kansas City | 17-31 |
| 11/12/06 | at | Seattle | 22-24 |
| 11/19/06 | at | Carolina | 0-15 |
| 11/26/06 | hosting | San Francisco | 20-17 |
| 12/03/06 | hosting | Arizona | 20-34 |
| 12/11/06 | hosting | Chicago | 27-42 |
| 12/17/06 | at | Oakland | 20-0 |
| 12/24/06 | hosting | Washington | 37-31 OT |
| 12/31/06 | at | Minnesota | 41-21 |