| 09/12/05 | hosting | Philadelphia | 14-10 |
| 09/18/05 | at | Seattle | 18-21 |
| 09/25/05 | at | Buffalo | 24-16 |
| 10/02/05 | hosting | Minnesota | 30-10 |
| 10/09/05 | hosting | New England | 28-31 |
| 10/16/05 | at | New Orleans | 34-31 |
| 10/24/05 | hosting | N.Y. Jets | 27-14 |
| 11/06/05 | at | Miami | 17-10 |
| 11/13/05 | hosting | Green Bay | 25-33 |
| 11/20/05 | hosting | Tampa Bay | 27-30 |
| 11/24/05 | at | Detroit | 27-7 |
| 12/04/05 | at | Carolina | 6-24 |
| 12/12/05 | hosting | New Orleans | 36-17 |
| 12/18/05 | at | Chicago | 3-16 |
| 12/24/05 | at | Tampa Bay | 24-27 OT |
| 01/01/06 | hosting | Carolina | 11-44 |