| 09/11/05 | at | Detroit | 3-17 |
| 09/18/05 | hosting | Cleveland | 24-26 |
| 09/25/05 | hosting | Tampa Bay | 16-17 |
| 10/03/05 | at | Carolina | 29-32 |
| 10/09/05 | hosting | New Orleans | 52-3 |
| 10/23/05 | at | Minnesota | 20-23 |
| 10/30/05 | at | Cincinnati | 14-21 |
| 11/06/05 | hosting | Pittsburgh | 10-20 |
| 11/13/05 | at | Atlanta | 33-25 |
| 11/21/05 | hosting | Minnesota | 17-20 |
| 11/27/05 | at | Philadelphia | 14-19 |
| 12/04/05 | at | Chicago | 7-19 |
| 12/11/05 | hosting | Detroit | 16-13 OT |
| 12/19/05 | at | Baltimore | 3-48 |
| 12/25/05 | hosting | Chicago | 17-24 |
| 01/01/06 | hosting | Seattle | 23-17 |