| 09/11/05 | hosting | Tennessee | 34-7 |
| 09/18/05 | at | Houston | 27-7 |
| 09/25/05 | hosting | New England | 20-23 |
| 10/10/05 | at | San Diego | 24-22 |
| 10/16/05 | hosting | Jacksonville | 17-23 OT |
| 10/23/05 | at | Cincinnati | 27-13 |
| 10/31/05 | hosting | Baltimore | 20-19 |
| 11/06/05 | at | Green Bay | 20-10 |
| 11/13/05 | hosting | Cleveland | 34-21 |
| 11/20/05 | at | Baltimore | 13-16 OT |
| 11/28/05 | at | Indianapolis | 7-26 |
| 12/04/05 | hosting | Cincinnati | 31-38 |
| 12/11/05 | hosting | Chicago | 21-9 |
| 12/18/05 | at | Minnesota | 18-3 |
| 12/24/05 | at | Cleveland | 41-0 |
| 01/01/06 | hosting | Detroit | 35-21 |
| 01/08/06 | at | Cincinnati | 31-17 |
| 01/15/06 | at | Indianapolis | 21-18 |
| 01/22/06 | at | Denver | 34-17 |
| 02/05/06 | vs. | Seattle | 21-10 |