| 09/11/05 | at | Jacksonville | 14-26 |
| 09/18/05 | hosting | Atlanta | 21-18 |
| 09/25/05 | hosting | Arizona | 37-12 |
| 10/02/05 | at | Washington | 17-20 OT |
| 10/09/05 | at | St. Louis | 37-31 |
| 10/16/05 | hosting | Houston | 42-10 |
| 10/23/05 | hosting | Dallas | 13-10 |
| 11/06/05 | at | Arizona | 33-19 |
| 11/13/05 | hosting | St. Louis | 31-16 |
| 11/20/05 | at | San Francisco | 27-25 |
| 11/27/05 | hosting | N.Y. Giants | 24-21 OT |
| 12/05/05 | at | Philadelphia | 42-0 |
| 12/11/05 | hosting | San Francisco | 41-0 |
| 12/18/05 | at | Tennessee | 28-24 |
| 12/24/05 | hosting | Indianapolis | 28-13 |
| 01/01/06 | at | Green Bay | 17-23 |
| 01/14/06 | hosting | Washington | 20-10 |
| 01/22/06 | hosting | Carolina | 34-14 |
| 02/05/06 | vs. | Pittsburgh | 10-21 |