| 09/11/05 | hosting | Seattle | 26-14 |
| 09/18/05 | at | Indianapolis | 3-10 |
| 09/25/05 | at | N.Y. Jets | 26-20 OT |
| 10/02/05 | hosting | Denver | 7-20 |
| 10/09/05 | hosting | Cincinnati | 23-20 |
| 10/16/05 | at | Pittsburgh | 23-17 OT |
| 10/30/05 | at | St. Louis | 21-24 |
| 11/06/05 | hosting | Houston | 21-14 |
| 11/13/05 | hosting | Baltimore | 30-3 |
| 11/20/05 | at | Tennessee | 31-28 |
| 11/27/05 | at | Arizona | 24-17 |
| 12/04/05 | at | Cleveland | 20-14 |
| 12/11/05 | hosting | Indianapolis | 18-26 |
| 12/18/05 | hosting | San Francisco | 10-9 |
| 12/24/05 | at | Houston | 38-20 |
| 01/01/06 | hosting | Tennessee | 40-13 |
| 01/07/06 | at | New England | 3-28 |