| 09/11/05 | at | N.Y. Giants | 19-42 |
| 09/18/05 | hosting | St. Louis | 12-17 |
| 09/25/05 | at | Seattle | 12-37 |
| 10/02/05 | vs. | San Francisco | 31-14 |
| 10/09/05 | hosting | Carolina | 20-24 |
| 10/23/05 | hosting | Tennessee | 20-10 |
| 10/30/05 | at | Dallas | 13-34 |
| 11/06/05 | hosting | Seattle | 19-33 |
| 11/13/05 | at | Detroit | 21-29 |
| 11/20/05 | at | St. Louis | 38-28 |
| 11/27/05 | hosting | Jacksonville | 17-24 |
| 12/04/05 | at | San Francisco | 17-10 |
| 12/11/05 | hosting | Washington | 13-17 |
| 12/18/05 | at | Houston | 19-30 |
| 12/24/05 | hosting | Philadelphia | 27-21 |
| 01/01/06 | at | Indianapolis | 13-17 |