| 09/11/05 | at | Baltimore | 24-7 |
| 09/18/05 | hosting | Jacksonville | 10-3 |
| 09/25/05 | hosting | Cleveland | 13-6 |
| 10/02/05 | at | Tennessee | 31-10 |
| 10/09/05 | at | San Francisco | 28-3 |
| 10/17/05 | hosting | St. Louis | 45-28 |
| 10/23/05 | at | Houston | 38-20 |
| 11/07/05 | at | New England | 40-21 |
| 11/13/05 | hosting | Houston | 31-17 |
| 11/20/05 | at | Cincinnati | 45-37 |
| 11/28/05 | hosting | Pittsburgh | 26-7 |
| 12/04/05 | hosting | Tennessee | 35-3 |
| 12/11/05 | at | Jacksonville | 26-18 |
| 12/18/05 | hosting | San Diego | 17-26 |
| 12/24/05 | at | Seattle | 13-28 |
| 01/01/06 | hosting | Arizona | 17-13 |
| 01/15/06 | hosting | Pittsburgh | 18-21 |