| 09/11/05 | hosting | St. Louis | 28-25 |
| 09/18/05 | at | Philadelphia | 3-42 |
| 09/25/05 | hosting | Dallas | 31-34 |
| 10/02/05 | vs. | Arizona | 14-31 |
| 10/09/05 | hosting | Indianapolis | 3-28 |
| 10/23/05 | at | Washington | 17-52 |
| 10/30/05 | hosting | Tampa Bay | 15-10 |
| 11/06/05 | hosting | N.Y. Giants | 6-24 |
| 11/13/05 | at | Chicago | 9-17 |
| 11/20/05 | hosting | Seattle | 25-27 |
| 11/27/05 | at | Tennessee | 22-33 |
| 12/04/05 | hosting | Arizona | 10-17 |
| 12/11/05 | at | Seattle | 0-41 |
| 12/18/05 | at | Jacksonville | 9-10 |
| 12/24/05 | at | St. Louis | 24-20 |
| 01/01/06 | hosting | Houston | 20-17 OT |