| 09/11/05 | at | Washington | 7-9 |
| 09/18/05 | hosting | Detroit | 38-6 |
| 09/25/05 | hosting | Cincinnati | 7-24 |
| 10/09/05 | at | Cleveland | 10-20 |
| 10/16/05 | hosting | Minnesota | 28-3 |
| 10/23/05 | hosting | Baltimore | 10-6 |
| 10/30/05 | at | Detroit | 19-13 OT |
| 11/06/05 | at | New Orleans | 20-17 |
| 11/13/05 | hosting | San Francisco | 17-9 |
| 11/20/05 | hosting | Carolina | 13-3 |
| 11/27/05 | at | Tampa Bay | 13-10 |
| 12/04/05 | hosting | Green Bay | 19-7 |
| 12/11/05 | at | Pittsburgh | 9-21 |
| 12/18/05 | hosting | Atlanta | 16-3 |
| 12/25/05 | at | Green Bay | 24-17 |
| 01/01/06 | at | Minnesota | 10-34 |
| 01/15/06 | hosting | Carolina | 21-29 |