| 09/11/05 | hosting | Chicago | 9-7 |
| 09/19/05 | at | Dallas | 14-13 |
| 10/02/05 | hosting | Seattle | 20-17 OT |
| 10/09/05 | at | Denver | 19-21 |
| 10/16/05 | at | Kansas City | 21-28 |
| 10/23/05 | hosting | San Francisco | 52-17 |
| 10/30/05 | at | N.Y. Giants | 0-36 |
| 11/06/05 | hosting | Philadelphia | 17-10 |
| 11/13/05 | at | Tampa Bay | 35-36 |
| 11/20/05 | hosting | Oakland | 13-16 |
| 11/27/05 | hosting | San Diego | 17-23 OT |
| 12/04/05 | at | St. Louis | 24-9 |
| 12/11/05 | at | Arizona | 17-13 |
| 12/18/05 | hosting | Dallas | 35-7 |
| 12/24/05 | hosting | N.Y. Giants | 35-20 |
| 01/01/06 | at | Philadelphia | 31-20 |
| 01/07/06 | at | Tampa Bay | 17-10 |
| 01/14/06 | at | Seattle | 10-20 |