| 09/08/05 | at | New England | 20-30 |
| 09/18/05 | hosting | Kansas City | 17-23 |
| 09/25/05 | at | Philadelphia | 20-23 |
| 10/02/05 | hosting | Dallas | 19-13 |
| 10/16/05 | hosting | San Diego | 14-27 |
| 10/23/05 | hosting | Buffalo | 38-17 |
| 10/30/05 | at | Tennessee | 34-25 |
| 11/06/05 | at | Kansas City | 23-27 |
| 11/13/05 | hosting | Denver | 17-31 |
| 11/20/05 | at | Washington | 16-13 |
| 11/27/05 | hosting | Miami | 21-33 |
| 12/04/05 | at | San Diego | 10-34 |
| 12/11/05 | at | N.Y. Jets | 10-26 |
| 12/18/05 | hosting | Cleveland | 7-9 |
| 12/24/05 | at | Denver | 3-22 |
| 12/31/05 | hosting | N.Y. Giants | 21-30 |