| 09/08/05 | hosting | Oakland | 30-20 |
| 09/18/05 | at | Carolina | 17-27 |
| 09/25/05 | at | Pittsburgh | 23-20 |
| 10/02/05 | hosting | San Diego | 17-41 |
| 10/09/05 | at | Atlanta | 31-28 |
| 10/16/05 | at | Denver | 20-28 |
| 10/30/05 | hosting | Buffalo | 21-16 |
| 11/07/05 | hosting | Indianapolis | 21-40 |
| 11/13/05 | at | Miami | 23-16 |
| 11/20/05 | hosting | New Orleans | 24-17 |
| 11/27/05 | at | Kansas City | 16-26 |
| 12/04/05 | hosting | N.Y. Jets | 16-3 |
| 12/11/05 | at | Buffalo | 35-7 |
| 12/17/05 | hosting | Tampa Bay | 28-0 |
| 12/26/05 | at | N.Y. Jets | 31-21 |
| 01/01/06 | hosting | Miami | 26-28 |
| 01/07/06 | hosting | Jacksonville | 28-3 |
| 01/14/06 | at | Denver | 13-27 |