| 09/11/05 | at | Miami | 10-34 |
| 09/18/05 | hosting | San Diego | 20-17 |
| 09/26/05 | hosting | Kansas City | 30-10 |
| 10/02/05 | at | Jacksonville | 20-7 |
| 10/09/05 | hosting | Washington | 21-19 |
| 10/16/05 | hosting | New England | 28-20 |
| 10/23/05 | at | N.Y. Giants | 23-24 |
| 10/30/05 | hosting | Philadelphia | 49-21 |
| 11/13/05 | at | Oakland | 31-17 |
| 11/20/05 | hosting | N.Y. Jets | 27-0 |
| 11/24/05 | at | Dallas | 24-21 OT |
| 12/04/05 | at | Kansas City | 27-31 |
| 12/11/05 | hosting | Baltimore | 12-10 |
| 12/17/05 | at | Buffalo | 28-17 |
| 12/24/05 | hosting | Oakland | 22-3 |
| 12/31/05 | at | San Diego | 23-7 |
| 01/14/06 | hosting | New England | 27-13 |
| 01/22/06 | hosting | Pittsburgh | 17-34 |