| 09/11/05 | hosting | Denver | 34-10 |
| 09/18/05 | at | N.Y. Jets | 7-17 |
| 09/25/05 | hosting | Carolina | 27-24 |
| 10/09/05 | at | Buffalo | 14-20 |
| 10/16/05 | at | Tampa Bay | 13-27 |
| 10/21/05 | hosting | Kansas City | 20-30 |
| 10/30/05 | at | New Orleans | 21-6 |
| 11/06/05 | hosting | Atlanta | 10-17 |
| 11/13/05 | hosting | New England | 16-23 |
| 11/20/05 | at | Cleveland | 0-22 |
| 11/27/05 | at | Oakland | 33-21 |
| 12/04/05 | hosting | Buffalo | 24-23 |
| 12/11/05 | at | San Diego | 23-21 |
| 12/18/05 | hosting | N.Y. Jets | 24-20 |
| 12/24/05 | hosting | Tennessee | 24-10 |
| 01/01/06 | at | New England | 28-26 |