| 09/11/05 | at | Carolina | 23-20 |
| 09/19/05 | at | N.Y. Giants | 10-27 |
| 09/25/05 | at | Minnesota | 16-33 |
| 10/02/05 | hosting | Buffalo | 19-7 |
| 10/09/05 | at | Green Bay | 3-52 |
| 10/16/05 | hosting | Atlanta | 31-34 |
| 10/23/05 | at | St. Louis | 17-28 |
| 10/30/05 | hosting | Miami | 6-21 |
| 11/06/05 | hosting | Chicago | 17-20 |
| 11/20/05 | at | New England | 17-24 |
| 11/27/05 | at | N.Y. Jets | 21-19 |
| 12/04/05 | hosting | Tampa Bay | 3-10 |
| 12/12/05 | at | Atlanta | 17-36 |
| 12/18/05 | hosting | Carolina | 10-27 |
| 12/24/05 | hosting | Detroit | 12-13 |
| 01/01/06 | at | Tampa Bay | 13-27 |