| 09/11/05 | hosting | Green Bay | 17-3 |
| 09/18/05 | at | Chicago | 6-38 |
| 10/02/05 | at | Tampa Bay | 13-17 |
| 10/09/05 | hosting | Baltimore | 35-17 |
| 10/16/05 | hosting | Carolina | 20-21 |
| 10/23/05 | at | Cleveland | 13-10 |
| 10/30/05 | hosting | Chicago | 13-19 OT |
| 11/06/05 | at | Minnesota | 14-27 |
| 11/13/05 | hosting | Arizona | 29-21 |
| 11/20/05 | at | Dallas | 7-20 |
| 11/24/05 | hosting | Atlanta | 7-27 |
| 12/04/05 | hosting | Minnesota | 16-21 |
| 12/11/05 | at | Green Bay | 13-16 OT |
| 12/18/05 | hosting | Cincinnati | 17-41 |
| 12/24/05 | at | New Orleans | 13-12 |
| 01/01/06 | at | Pittsburgh | 21-35 |