| 09/11/05 | at | Cleveland | 27-13 |
| 09/18/05 | hosting | Minnesota | 37-8 |
| 09/25/05 | at | Chicago | 24-7 |
| 10/02/05 | hosting | Houston | 16-10 |
| 10/09/05 | at | Jacksonville | 20-23 |
| 10/16/05 | at | Tennessee | 31-23 |
| 10/23/05 | hosting | Pittsburgh | 13-27 |
| 10/30/05 | hosting | Green Bay | 21-14 |
| 11/06/05 | at | Baltimore | 21-9 |
| 11/20/05 | hosting | Indianapolis | 37-45 |
| 11/27/05 | hosting | Baltimore | 42-29 |
| 12/04/05 | at | Pittsburgh | 38-31 |
| 12/11/05 | hosting | Cleveland | 23-20 |
| 12/18/05 | at | Detroit | 41-17 |
| 12/24/05 | hosting | Buffalo | 27-37 |
| 01/01/06 | at | Kansas City | 3-37 |
| 01/08/06 | hosting | Pittsburgh | 17-31 |