| 09/11/05 | hosting | Indianapolis | 7-24 |
| 09/18/05 | at | Tennessee | 10-25 |
| 10/02/05 | hosting | N.Y. Jets | 13-3 |
| 10/09/05 | at | Detroit | 17-35 |
| 10/16/05 | hosting | Cleveland | 16-3 |
| 10/23/05 | at | Chicago | 6-10 |
| 10/31/05 | at | Pittsburgh | 19-20 |
| 11/06/05 | hosting | Cincinnati | 9-21 |
| 11/13/05 | at | Jacksonville | 3-30 |
| 11/20/05 | hosting | Pittsburgh | 16-13 OT |
| 11/27/05 | at | Cincinnati | 29-42 |
| 12/04/05 | hosting | Houston | 16-15 |
| 12/11/05 | at | Denver | 10-12 |
| 12/19/05 | hosting | Green Bay | 48-3 |
| 12/25/05 | hosting | Minnesota | 30-23 |
| 01/01/06 | at | Cleveland | 16-20 |