| 09/11/05 | hosting | Cincinnati | 13-27 |
| 09/18/05 | at | Green Bay | 26-24 |
| 09/25/05 | at | Indianapolis | 6-13 |
| 10/09/05 | hosting | Chicago | 20-10 |
| 10/16/05 | at | Baltimore | 3-16 |
| 10/23/05 | hosting | Detroit | 10-13 |
| 10/30/05 | at | Houston | 16-19 |
| 11/06/05 | hosting | Tennessee | 20-14 |
| 11/13/05 | at | Pittsburgh | 21-34 |
| 11/20/05 | hosting | Miami | 22-0 |
| 11/27/05 | at | Minnesota | 12-24 |
| 12/04/05 | hosting | Jacksonville | 14-20 |
| 12/11/05 | at | Cincinnati | 20-23 |
| 12/18/05 | at | Oakland | 9-7 |
| 12/24/05 | hosting | Pittsburgh | 0-41 |
| 01/01/06 | hosting | Baltimore | 20-16 |