| 09/11/05 | at | Buffalo | 7-22 |
| 09/18/05 | hosting | Pittsburgh | 7-27 |
| 10/02/05 | at | Cincinnati | 10-16 |
| 10/09/05 | hosting | Tennessee | 20-34 |
| 10/16/05 | at | Seattle | 10-42 |
| 10/23/05 | hosting | Indianapolis | 20-38 |
| 10/30/05 | hosting | Cleveland | 19-16 |
| 11/06/05 | at | Jacksonville | 14-21 |
| 11/13/05 | at | Indianapolis | 17-31 |
| 11/20/05 | hosting | Kansas City | 17-45 |
| 11/27/05 | hosting | St. Louis | 27-33 OT |
| 12/04/05 | at | Baltimore | 15-16 |
| 12/11/05 | at | Tennessee | 10-13 |
| 12/18/05 | hosting | Arizona | 30-19 |
| 12/24/05 | hosting | Jacksonville | 20-38 |
| 01/01/06 | at | San Francisco | 17-20 OT |