| 09/11/05 | at | Pittsburgh | 7-34 |
| 09/18/05 | hosting | Baltimore | 25-10 |
| 09/25/05 | at | St. Louis | 27-31 |
| 10/02/05 | hosting | Indianapolis | 10-31 |
| 10/09/05 | at | Houston | 34-20 |
| 10/16/05 | hosting | Cincinnati | 23-31 |
| 10/23/05 | at | Arizona | 10-20 |
| 10/30/05 | hosting | Oakland | 25-34 |
| 11/06/05 | at | Cleveland | 14-20 |
| 11/20/05 | hosting | Jacksonville | 28-31 |
| 11/27/05 | hosting | San Francisco | 33-22 |
| 12/04/05 | at | Indianapolis | 3-35 |
| 12/11/05 | hosting | Houston | 13-10 |
| 12/18/05 | hosting | Seattle | 24-28 |
| 12/24/05 | at | Miami | 10-24 |
| 01/01/06 | at | Jacksonville | 13-40 |