| 09/11/05 | at | San Francisco | 25-28 |
| 09/18/05 | at | Arizona | 17-12 |
| 09/25/05 | hosting | Tennessee | 31-27 |
| 10/02/05 | at | N.Y. Giants | 24-44 |
| 10/09/05 | hosting | Seattle | 31-37 |
| 10/17/05 | at | Indianapolis | 28-45 |
| 10/23/05 | hosting | New Orleans | 28-17 |
| 10/30/05 | hosting | Jacksonville | 24-21 |
| 11/13/05 | at | Seattle | 16-31 |
| 11/20/05 | hosting | Arizona | 28-38 |
| 11/27/05 | at | Houston | 33-27 OT |
| 12/04/05 | hosting | Washington | 9-24 |
| 12/11/05 | at | Minnesota | 13-27 |
| 12/18/05 | hosting | Philadelphia | 16-17 |
| 12/24/05 | hosting | San Francisco | 20-24 |
| 01/01/06 | at | Dallas | 20-10 |